Homocysteine-lowering interventions for preventing cardiovascular events

Homocysteine lowering and cardiovascular events after acute myocardial infarction.

BACKGROUND Homocysteine is a risk factor for cardiovascular disease. We evaluated the efficacy of homocysteine-lowering treatment with B vitamins for secondary prevention in patients who had had an acute myocardial infarction. METHODS The trial included 3749 men and women who had had an acute myocardial infarction within seven days before randomization. Patients were randomly assigned, in a t...

Baseline albuminuria predicts the efficacy of blood pressure-lowering drugs in preventing cardiovascular events.

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Albuminuria has been proven to be associated with cardiovascular morbidity and mortality. Such an association has been found not only in subjects with diabetes and hypertension, but also in the general population. It could therefore be expected that especially subjects with higher albuminuria levels may benefit from blood pressure-lowering agents to impr...

Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial.

CONTEXT Observational studies have reported associations between circulating total homocysteine concentration and risk of cardiovascular disease. Oral administration of folic acid and vitamin B(12) can lower plasma total homocysteine levels. OBJECTIVE To assess the effect of treatment with folic acid and vitamin B(12) and the effect of treatment with vitamin B(6) as secondary prevention in pa...

Preventing cardiovascular events with empagliflozin: at what cost?

Vitamin D and statins: action in preventing cardiovascular events.

INTRODUCTION Statins are widely used compounds in hypercholesterolemic patients reducing the risk of cardiovascular (CV) events. As a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are extremely effective at reducing low-density lipoprotein (LDL) cholesterol and have been demonstrated to reduce mortality and the risk of coronary heart disease (CHD) in a number of large pri...